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Molecule Parameter List for IP4(1456)_ER

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP4(1456)_ER participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	1	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP4(1456)_ER acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP4(1456)_ER	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	0	160	No

IP4(1456)_ER acting as a Product of an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
MIPP  / ip5_3pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	0.0400005	0.2321	4	explicit E-S complex	Substrate IP5(13456)_ER Product IP4(1456)_ER
Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991

IP4(1456)_ER acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
ip4(1456)_trp	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	1 (s^-1)	0.001 (s^-1)	Not applicable**	-	Substrate IP4(1456)_ER Product IP4(1456)
Ins(1456)P4 ER-cytosol transport

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration