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Molecule Parameter List for MIPP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

MIPP participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	3	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

MIPP acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
MIPP	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	0.398	160	No
Multiple Inositol Polyphosphate Phosphatase from Nogimori et al, JBC 266(25); 1991: 16499-506 MIPP clustered in ER. Distinct transporters present for cytosolic substrates. Accounts for 30-45% of total 3-phosphatase activity against substrates, hence cytosolic counterparts of this enzyme must be present (as per Chi et al, MCB 20; 2000: 6496-507)

MIPP acting as an Enzyme in  NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	MIPP / ip5_3pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	0.0400005	0.2321	4	explicit E-S complex	Substrate IP5(13456)_ER Product IP4(1456)_ER
	Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991
2	MIPP / ip4_3pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	0.13	4.675	4	explicit E-S complex	Substrate IP4(1345)_ER Product IP3(145)_ER
	Ins(1345)P4 3-phosphatase from Nogimori et al, JBC 266; 1991
3	MIPP / ip6_pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	0.000299996	0.0132	4	explicit E-S complex	Substrate IP6_ER Product IP5(12456)_ER IP5(13456)_ER
	InsP6 2/3-phosphatase from Nogimori et al, JBC 266; 1991