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Molecule Parameter List for IP3_3K*1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP3_3K*1 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	1	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP3_3K*1 acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP3_3K*1	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP3-3K Pathway No. : 109	0	1000	No
Sim et al; JBC 265(18) June 25; 1990: pp 10367-10372 Phos. at 2 major sites = Ser109 & Ser 175; but there is a possibility that inactivation is due to combined effect of multiple phosphorylations activity suppressed by 75%

IP3_3K*1 acting as an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP3_3K*1 / ip3-3k*1	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP3-3K Pathway No. : 109	1.40004	0.76187	4.00003	explicit E-S complex	Substrate IP3(145) Product IP4(1345)
from Sim et al, JBC 265; 1990

IP3_3K*1 acting as a Product of an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PKC-active  / PKC-phos	NonOsc_Ca_ IP3metabolism Accession No. : 23	PKC Pathway No. : 108	30.0008	4	4	explicit E-S complex	Substrate IP3_3K Product IP3_3K*1
rates referred from standard PKC phosphorylation rates