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Molecule Parameter List for Ca-sequester

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*Ca-sequester* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	9	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP, CaMKII, CaM, PKC, IP3-3K, CaRegulation, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

Ca-sequester acting as a Molecule in NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Ca-sequester	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	5.796	160	No
Sequestered Ca pool The vol is 0.16 the vol of the cell as a whole.*

Ca-sequester acting as a Substrate in a reaction in NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Ca5-bind-Cal	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Substrate Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Calseq Product Ca5-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with one Calseq. Due to system limitations only four are entered.
2	inactivate_cap_ Ca	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0 (#^-2 s^-1)	1 (s^-1)	Not applicable**	-	Substrate Ca-sequester Ca-sequester capacitive_Ca_ entry* Product inact_cap_entry
	The Kd is set at about 3 uM so that at resting Ca the capacitative Ca entry is almost blocked. A 2nd order response makes the response steep.
3	Ca10-bind-Cal	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Substrate Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca5-Cal Product Ca10-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca5-Cal. Due to system limitations only four are entered.
4	Ca15-bind-Cal	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Substrate Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca10-Cal Product Ca15-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca10-Cal. Due to system limitations only four are entered.
5	Ca20-bind-Cal	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Substrate Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca15-Cal Product Ca20-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca15-Cal. Due to system limitations only four are entered.
6	Ca25-bind-Cal	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Substrate Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca20-Cal Product Ca25-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca20-Cal. Due to system limitations only four are entered.
7	Ca30-bind-Cal	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Substrate Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca25-Cal Product Ca30-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca25-Cal. Due to system limitations only four are entered.
8	Ca35-bind-Cal	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Substrate Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca30-Cal Product Ca35-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca30-Cal. Due to system limitations only four are entered.
9	Ca40-bind-Cal	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.0005 (uM^-5 s^-1)	1 (s^-1)	-	-	Substrate Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca-sequester Ca35-Cal Product Ca40-Cal
	There are actually 5 Ca-sequester substrates for this reaction, along with Ca35-Cal. Due to system limitations only four are entered.

Ca-sequester acting as a Product in a reaction in NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaTraspATPase	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	25 (s^-1)	0 (#^-2 s^-1)	Not applicable**	-	Substrate CaTransp-2Ca Product Ca-sequester Ca-sequester CaTransp
kCa3 = 2 * Ca transporter rate since each step has 2 Ca++. = 0.5 uM/sec from Lauffenburger and Linderman 1993 Receptors pg200 The amount of the activated transporter is about 0.01 uM = 6e3#. from runs. So 0.01uM * kf * 2 = 0.5 uM/sec (no back reaction) so kf = 25, kb = 0 Alternatively, 6e3 * kf = 0.25 * 6e5, giving the same kf

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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