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Molecule Parameter List for IP3R*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP3R* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP3R* acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP3R*	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0	1000	No
This is the ligand-bound form of the IP3R.

IP3R* acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
IP3Rbind	NonOsc_Ca_ IP3metabolism Accession No. : 23	CaRegulation Pathway No. : 110	0.05 (uM^-3 s^-1)	1 (s^-1)	Kd(af) = 2.7144(uM)	-	Substrate IP3 IP3 IP3 IP3R Product IP3R*
Based on Lauffenburger and Linderman 1993 Receptors pg 200. The binding of IP3 on this reaction had a Hill coeff of 3. The eqns of Mahama and Linderman (cited in the book as 1993 a) are equivalent to the binding all occurring in a single step, so that is how I do it in this version. Their Ki1 is 0.07 uM. Lots of other data sources: Ramos-Franco et al, Biophys J 75, 1998: 834-39 have Ca sensitivity curves. At 250 nM free Ca, the EC50 for type1 is 58 nM and type 2 is 194 nM. Type 3 would be about 2 uM according to Newton et al, JBC 268(46), 1994: 28613-19. For the purposes of this model we use a Kd of 2.7 uM which is high but maybe OK at low calcium. The details of Ca interaction with the IP3R are not included in this model.