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Molecule Parameter List for IP2(13)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP2(13) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	1	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP2(13) acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP2(13)	NonOsc_Ca_ IP3metabolism Accession No. : 23	134_dephos Pathway No. : 113	0	1000	No
Inositol (13)bisphosphate according to Batty et al (Biochem J 258(1); 1989: 23-32) Ins(13)P2 forms 22% of all InsP2 in cerebral cortex slices. Our simulations generate similar basal levels

IP2(13) acting as a Substrate for an Enzyme in  NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP2_3pase2  / ip2_3pase2	NonOsc_Ca_ IP3metabolism Accession No. : 23	134_dephos Pathway No. : 113	3.70001	39.2	4	explicit E-S complex	Substrate IP2(13) Product IP1(1)
	from Caldwell et al, JBC 266; 1991
2	IP2_3pase1  / ip2_3pase1	NonOsc_Ca_ IP3metabolism Accession No. : 23	134_dephos Pathway No. : 113	0.799992	117.33	4	explicit E-S complex	Substrate IP2(13) Product IP1(1)
	from Caldwell et al, JBC 266; 1991 enzyme activity was assayed for the monomeric form of the enzyme

IP2(13) acting as a Product of an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP_4pase  / ip3_4pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	134_dephos Pathway No. : 113	20.0014	20	4	explicit E-S complex	Substrate IP3(134) Product IP2(13)
Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2