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Molecule Parameter List for IP3_5pase2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP3_5pase2 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP3_5pase2 acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP3_5pase2	NonOsc_Ca_ IP3metabolism Accession No. : 23	145_dephos Pathway No. : 114	0.463	1000	No
from Hansen et al, JBC 262(36), Dec 25 1987: 17319-17326

IP3_5pase2 acting as an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP3_5pase2 / ip3_5pase2	NonOsc_Ca_ IP3metabolism Accession No. : 23	145_dephos Pathway No. : 114	18.0004	10.667	3.99991	explicit E-S complex	Substrate IP3(145) Product IP2(14)
from Hansen et al, JBC 262, 1987 activity determined from pH curve. Value scaled 1.5 times to obtain activity at 37C as original experiment was performed at 30C