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Molecule Parameter List for IP3-56Kcmplx

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*IP3-56Kcmplx* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	4	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP, CaMKII, CaM, PKC, IP3-3K, CaRegulation, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP3-56Kcmplx acting as a Molecule in NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP3-56Kcmplx	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0	1000	No
enzyme substrate complex of IP3 56-K and Ins(134)P3

IP3-56Kcmplx acting as a Substrate in a reaction in NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	ip4-inhib-56k[1]	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	1 (uM^-1 s^-1)	6.3 (s^-1)	Kd(bf) = 6.3(uM)	-	Substrate IP3-56Kcmplx IP4(1345) Product IP4(1345)-56k-cm plx
	from Shears, JBC 264(33); 1989: 19879-86
2	ip4-inhib-56k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	1 (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate IP3-56Kcmplx IP4(3456) Product IP4(3456)-56k-cm plx
	from Hughes et al, JBC 264(33); 1989: 19871-78
3	6kinase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.048 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate IP3-56Kcmplx Product IP3-56K IP4(1346)
	Kf = Vmax for IP3 56K from Wilson and Majerus, JBC 271; 1996
4	5kinase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.0132 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate IP3-56Kcmplx Product IP3-56K IP4(1345)
	Kf = 0.274 times Vmax of IP3 56-K as product ratio of Ins(1345)P4 : Ins(1346)P4 is 1 : 2.3-5 from Wilson and Majerus, JBC 271; 1996

IP3-56Kcmplx acting as a Product in a reaction in NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
IP3-Kcmplx-on	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	3 (uM^-1 s^-1)	0.192 (s^-1)	Kd(bf) = 0.064(uM)	-	Substrate IP3(134) IP3-56K Product IP3-56Kcmplx
Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from Km and Vmax values provided by Wilson and Majerus, JBC 271; 1996

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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