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Molecule Parameter List for IP1(1) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP1(1) acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP1(1) | Osc_Ca_
IP3metabolism
Accession No. : 24 | 134_dephos
Pathway No. : 127 | 0 | 1000 | No | | Inositol (1)monophsophate According to Gee et al (Biochem J 249; 1988: 888) Ins(1)P conc upto 44 uM. But this is mainly from phosphotidylinositol lipid metabolism that we have not considered. |
IP1(1) acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP1_pase /
ip1_1pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | 145_dephos
Pathway No. : 128 | 160.001 | 11.43 | 4 | explicit E-S complex | Substrate
IP1(1)
Product
inositol
| | from Gee et al, Biochem J 249; 1988 |
IP1(1) acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP2_3pase2 /
ip2_3pase2 | Osc_Ca_
IP3metabolism
Accession No. : 24 | 134_dephos
Pathway No. : 127 | 3.70001 | 39.2 | 4 | explicit E-S complex | Substrate
IP2(13)
Product
IP1(1)
| | | from Caldwell et al, JBC 266; 1991 | | 2 | IP2_3pase1 /
ip2_3pase1 | Osc_Ca_
IP3metabolism
Accession No. : 24 | 134_dephos
Pathway No. : 127 | 0.799992 | 117.33 | 4 | explicit E-S complex | Substrate
IP2(13)
Product
IP1(1)
| | | from Caldwell et al, JBC 266; 1991 enzyme activity was assayed for the monomeric form of the enzyme |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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