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Molecule Parameter List for bisPP-IP3 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| bisPP-IP3 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 2 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
bisPP-IP3 acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | bisPP-IP3 | Osc_Ca_
IP3metabolism
Accession No. : 24 | IHP-system
Pathway No. : 130 | 0 | 1000 | Yes | | Bis(diphospho)inositol trisphosphate from Saiardi et al, JBC 275(32); 2000: 24686-92 |
bisPP-IP3 acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP6_K2 /
pp-ip4-k2 | Osc_Ca_
IP3metabolism
Accession No. : 24 | IHP-system
Pathway No. : 130 | 30.0003 | 0.01 | 4 | explicit E-S complex | Substrate
PP-IP4
Product
bisPP-IP3
| | | from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants | | 2 | IP6-K /
pp-ip4-k1 | Osc_Ca_
IP3metabolism
Accession No. : 24 | IHP-system
Pathway No. : 130 | 23.0003 | 0.05 | 4 | explicit E-S complex | Substrate
PP-IP4
Product
bisPP-IP3
| | | from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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