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Molecule Parameter List for tot_CaM_CaMKII | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| tot_CaM_CaMKII participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 1 | 4 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
tot_CaM_CaMKII acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | tot_CaM_CaMKII | Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 0 | 1000 | No | | This pool sums the levels of the CaM-bound forms of CaMKII: CaMKII-CaM + CaMKII-thr286*-CaM. Although their phosphorylation states are different, the level of activity is about the same so it makes sense to sum the levels. Hanson et al 1994 Neuron 12:943-956 |
tot_CaM_CaMKII acting as a Summed Molecule in Osc_Ca_IP3metabolism Network
| Accession Name | Pathway Name | Target | Input | Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | tot_CaM_CaMKII | CaMKII-CaM
CaMKII-thr286*-C
aM
| | This pool sums the levels of the CaM-bound forms of CaMKII: CaMKII-CaM + CaMKII-thr286*-CaM. Although their phosphorylation states are different, the level of activity is about the same so it makes sense to sum the levels. Hanson et al 1994 Neuron 12:943-956 |
tot_CaM_CaMKII acting as an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | tot_CaM_CaMKII /
CaM_act_305
| Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 0.00000270563 | 6 | 4 | explicit E-S complex | Substrate
CaMKII-thr286
Product
CaMKII***
| | | Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5. | | 2 | tot_CaM_CaMKII /
CaM_act_286
| Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 0.00000270563 | 0.5 | 4 | explicit E-S complex | Substrate
CaMKII-CaM
Product
CaMKII-thr286*-C
aM
| | | See Hanson and Schulman 1992 JBC 267(24):17216-17224 | | 3 | tot_CaM_CaMKII /
CaM-CaMK-phos
| Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 1.60001 | 0.5 | 4 | explicit E-S complex | Substrate
IP3_3K
Product
IP3_3K*
| | | rates referred from standard CaM-CaMKII phosphorylation rates | | 4 | tot_CaM_CaMKII /
CaM-CaMK-phos1
| Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 1.59998 | 0.5 | 4 | explicit E-S complex | Substrate
IP3_3K_CaM
Product
IP3_3K_CaM*
| | | rates referred from standard CaM-CaMKII phosphorylation rates |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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