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Molecule Parameter List for cAMP4.R2C

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
cAMP4.R2C participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
cAMP_pathway25Network
Shared_Object_cAMP_pathway,  PKA,  AC,  
Gs 
This is a model of the canonical cAMP signaling pathway:
Ligand->Receptor->G-protein->Cyclase->cAMP->PKA.
It also includes phosphodiesterases to balance out cAMP formation.Bhalla US Methods Enzymol. 2002;345:3-23

cAMP4.R2C acting as a Molecule in  cAMP_pathway Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
cAMP4.R2CcAMP_pathway
Accession No. : 25		PKA
Pathway No. : 135		01000No

cAMP4.R2C acting as a Substrate in a reaction in  cAMP_pathway Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Release-C2cAMP_pathway
Accession No. : 25		PKA
Pathway No. : 135		60
(s^-1)		18
(uM^-1 s^-1)		Kd(cb) = 0.3(uM)-Substrate
cAMP4.R2C

Product
PKA-active
cAMP4.R2

cAMP4.R2C acting as a Product in a reaction in  cAMP_pathway Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Release-C1cAMP_pathway
Accession No. : 25		PKA
Pathway No. : 135		60
(s^-1)		18
(uM^-1 s^-1)		Kd(cb) = 0.3(uM)-Substrate
cAMP4.R2C2

Product
PKA-active
cAMP4.R2C
This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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