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Molecule Parameter List for degraded-PKC

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*degraded-PKC* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	0	6

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
PKC_turnover	26	Pathway	PKC
This model is a superset of the PKC model presented in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. The current version includes PKC turnover. This version includes the stimulating pools Ca, AA and DAG as well as the PKC activity within the synaptic signaling pathway since it is meant to be a self-contained pathway model rather than part of a network.

degraded-PKC acting as a Molecule in PKC_turnover Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
degraded-PKC	PKC_turnover Accession No. : 26	PKC Pathway No. : 138	0	1000	Yes
This represents the ubiquitination and eventual removal of the PKC. See Lu et al 1998 Mol Cell Biol 18(2):839-845

degraded-PKC acting as a Product in a reaction in PKC_turnover Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PKC-downreg_ basal	PKC_turnover Accession No. : 26	PKC Pathway No. : 138	0 (s^-1)	0 (s^-1)	-	-	Substrate PKC-basal* Product degraded-PKC
	Typical rate for downreg is 6 hours. The downregulation appears to occur by a suicide mechanism in which the active PKC gets ubiquinated and degraded. The reference for this is Lu Z, Liu D, Hornia A, Devonish W, Pagana M and Foster DA 1998 Mol Cell Biol 18(2):839-845. I assume all activated forms of PKC downreg at the same rate.
2	PKC-Ca_downreg	PKC_turnover Accession No. : 26	PKC Pathway No. : 138	0 (s^-1)	0 (s^-1)	-	-	Substrate PKC-Ca-memb* Product degraded-PKC
	Typical rate for downreg is 6 hours. The downregulation appears to occur by a suicide mechanism in which the active PKC gets ubiquinated and degraded. The reference for this is Lu Z, Liu D, Hornia A, Devonish W, Pagana M and Foster DA 1998 Mol Cell Biol 18(2):839-845. I assume all activated forms of PKC downreg at the same rate.
3	PKC-DAG_downreg	PKC_turnover Accession No. : 26	PKC Pathway No. : 138	0 (s^-1)	0 (s^-1)	-	-	Substrate PKC-DAG-memb* Product degraded-PKC
	Typical rate for downreg is 6 hours. The downregulation appears to occur by a suicide mechanism in which the active PKC gets ubiquinated and degraded. The reference for this is Lu Z, Liu D, Hornia A, Devonish W, Pagana M and Foster DA 1998 Mol Cell Biol 18(2):839-845. I assume all activated forms of PKC downreg at the same rate.
4	PKC-Ca-AA_ downreg	PKC_turnover Accession No. : 26	PKC Pathway No. : 138	0 (s^-1)	0 (s^-1)	-	-	Substrate PKC-Ca-AA* Product degraded-PKC
	Typical rate for downreg is 6 hours. The downregulation appears to occur by a suicide mechanism in which the active PKC gets ubiquinated and degraded. The reference for this is Lu Z, Liu D, Hornia A, Devonish W, Pagana M and Foster DA 1998 Mol Cell Biol 18(2):839-845. I assume all activated forms of PKC downreg at the same rate.
5	PKC-DAG-AA_ downreg	PKC_turnover Accession No. : 26	PKC Pathway No. : 138	0 (s^-1)	0 (s^-1)	-	-	Substrate PKC-DAG-AA* Product degraded-PKC
	Typical rate for downreg is 6 hours. The downregulation appears to occur by a suicide mechanism in which the active PKC gets ubiquinated and degraded. The reference for this is Lu Z, Liu D, Hornia A, Devonish W, Pagana M and Foster DA 1998 Mol Cell Biol 18(2):839-845. I assume all activated forms of PKC downreg at the same rate.
6	PKC-AA_downreg	PKC_turnover Accession No. : 26	PKC Pathway No. : 138	0 (s^-1)	0 (s^-1)	-	-	Substrate PKC-AA* Product degraded-PKC
	Typical rate for downreg is 6 hours. The downregulation appears to occur by a suicide mechanism in which the active PKC gets ubiquinated and degraded. The reference for this is Lu Z, Liu D, Hornia A, Devonish W, Pagana M and Foster DA 1998 Mol Cell Biol 18(2):839-845. I assume all activated forms of PKC downreg at the same rate.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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