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Molecule Parameter List for MKKK | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
MKKK acting as a Molecule in MAPK_osc Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | MKKK | MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0.1 | 0.0016667 | No | | The total concn. of MKKK is 100nM from Kholodenko, 2000 |
MKKK acting as a Substrate for an Enzyme in MAPK_osc Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | Ras-MKKKK /
1 | MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0.01 | 2.5 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
MKKK
Product
MKKK-P
| | The Km is 10nM and Vmax is 2.5nM sec^-1. We assume that there is 1 nM of the Ras-MKKKK. From Kholodenko, 2000. If the enzymes are not flagged as Available, then this Km should be set to 0.1 to obtain oscillations. |
MKKK acting as a Product of an Enzyme in MAPK_osc Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | int1 /
2 | MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0.008 | 0.25 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
MKKK-P
Product
MKKK
| | Km is 8nM and Vmax is 0.25nM.s-1 from Kholodenko, 2000. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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