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Molecule Parameter List for MKKK-P | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
MKKK-P acting as a Molecule in MAPK_osc Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | MKKK-P | MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0 | 0.0016667 | No | | This is the phosphorylated form of MKKK which converts MKK to MKK-P and then to MKK-PP from Kholodenko, 2000. |
MKKK-P acting as an Enzyme in MAPK_osc Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | MKKK-P /
3
| MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0.0150001 | 0.025 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
MKK
Product
MKK-P
| | | Km is 15 nM and Vmax is 0.025s-1 from Kholodenko, 2000 | | 2 | MKKK-P /
4
| MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0.0150001 | 0.025 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
MKK-P
Product
MKK-PP
| | | Km is 15nM and Vmax is 0.025s-1 from Kholodenko, 2000. |
MKKK-P acting as a Substrate for an Enzyme in MAPK_osc Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | int1 /
2 | MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0.008 | 0.25 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
MKKK-P
Product
MKKK
| | Km is 8nM and Vmax is 0.25nM.s-1 from Kholodenko, 2000. |
MKKK-P acting as a Product of an Enzyme in MAPK_osc Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | Ras-MKKKK /
1 | MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0.01 | 2.5 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
MKKK
Product
MKKK-P
| | The Km is 10nM and Vmax is 2.5nM sec^-1. We assume that there is 1 nM of the Ras-MKKKK. From Kholodenko, 2000. If the enzymes are not flagged as Available, then this Km should be set to 0.1 to obtain oscillations. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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