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Molecule Parameter List for IP3(134)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP3(134) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	1	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	31	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP3(134) acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP3(134)	NonOsc_Ca_ IP3metabolism Accession No. : 31	IP4-system Pathway No. : 154	0	1000	No
Inositol (134)trisphosphate

IP3(134) acting as a Substrate for an Enzyme in  NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP_4pase  / ip3_4pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	134_dephos Pathway No. : 152	20.0014	20	4	explicit E-S complex	Substrate IP3(134) Product IP2(13)
	Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2
2	IP_1pase  / ip3_1pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	145_dephos Pathway No. : 153	20.0021	4.125	4	explicit E-S complex	Substrate IP3(134) Product IP2(34)
	Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987

IP3(134) acting as a Product of an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP_5pase1  / ip4_5pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	145_dephos Pathway No. : 153	0.80003	0.09	4	explicit E-S complex	Substrate IP4(1345) Product IP3(134)
Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3

IP3(134) acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	IP3-Kcmplx-on	NonOsc_Ca_ IP3metabolism Accession No. : 31	IP4-system Pathway No. : 154	4.2666 (uM^-1 s^-1)	1.024 (s^-1)	Kd(bf) = 0.24(uM)	-	Substrate IP3(134) IP3-56K_IP4-1K Product IP3-56Kcmplx
	Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from enzyme Km and Vmax: Yang and Shears, BiochemJ 2000, 351: 551-555
2	134-inhib-3pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	1345_dephos Pathway No. : 156	1 (uM^-1 s^-1)	2 (s^-1)	Kd(bf) = 2(uM)	-	Substrate 1345_3pase IP3(134) Product IP3(134)-3pase-c mplx
	from Hoer et al, Biochem J 270; 1990