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Molecule Parameter List for IP_1pase

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP_1pase participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP_1pase acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP_1pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 145_dephos
    Pathway No. : 153
    5.01631000No
    from Inhorn and Majerus; JBC 262(33), 1987 pp 15946-15952 InsP-1-phosphatase has two enzyme activities against Ins(14)P2 and Ins(134)P3 respectively

    IP_1pase acting as an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP_1pase /
    ip2_1pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 145_dephos
    Pathway No. : 153
    5.0000524explicit E-S complexSubstrate
    IP2(14)

    Product
    IP1(4)
        from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)
    2IP_1pase /
    ip3_1pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 145_dephos
    Pathway No. : 153
    20.00214.1254explicit E-S complexSubstrate
    IP3(134)

    Product
    IP2(34)
        Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987

    IP_1pase acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Ca-inhib-1pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 145_dephos
    Pathway No. : 153
    1
    (uM^-1 s^-1)
    6
    (s^-1)
    Kd(bf) = 5.9999(uM)-Substrate
    Ca
    IP_1pase

    Product
    Ca-1pase-cmplx
    Ki from Inhorn & Majerus, BiochemJ 262(33); 1987: 15946-52



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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