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Molecule Parameter List for PP-IP4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PP-IP4* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	2	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	31	Network	MIPP, CaMKII, CaM, PKC, IP3-3K, CaRegulation, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

PP-IP4 acting as a Molecule in NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP-IP4	NonOsc_Ca_ IP3metabolism Accession No. : 31	IHP-system Pathway No. : 155	14.9999	1000	No
Diphosphoinositol tetrakisphosphate Conc from Saiardi et al, JBC 275; 2000

PP-IP4 acting as a Substrate for an Enzyme in NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP6_K2 / pp-ip4-k2	NonOsc_Ca_ IP3metabolism Accession No. : 31	IHP-system Pathway No. : 155	30.0003	0.01	4	explicit E-S complex	Substrate PP-IP4 Product bisPP-IP3
	from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants
2	IP6-K / pp-ip4-k1	NonOsc_Ca_ IP3metabolism Accession No. : 31	IHP-system Pathway No. : 155	23.0003	0.05	4	explicit E-S complex	Substrate PP-IP4 Product bisPP-IP3
	from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants

PP-IP4 acting as a Product of an Enzyme in NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP6_K2 / ip5_k2	NonOsc_Ca_ IP3metabolism Accession No. : 31	IHP-system Pathway No. : 155	8.4	0.0572	4	explicit E-S complex	Substrate IP5(13456) Product PP-IP4
	from Saiardi et al, JBC 275(32); 2000: 24686-92
2	IP6-K / ip5_k1	NonOsc_Ca_ IP3metabolism Accession No. : 31	IHP-system Pathway No. : 155	6.69999	0.234	4	explicit E-S complex	Substrate IP5(13456) Product PP-IP4
	from Saiardi et al, JBC 275(32); 2000: 24686-92

PP-IP4 acting as a Substrate in a reaction in NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dipp_ip6	NonOsc_Ca_ IP3metabolism Accession No. : 31	IHP-system Pathway No. : 155	0 (s^-1)	0 (s^-1)	-	-	Substrate PP-IP4 Product IP5(13456)
rate based on basal levels of PP-InsP4

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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