NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for IP5(13456)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP5(13456) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002065

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP5(13456) acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP5(13456)
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    53.99921000No
    Inositol(13456)pentakisphosphate Conc from Voglmaier et al, PNAS 93; 1996

    IP5(13456) acting as a Substrate for an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP6_K2  /
    ip5_k2
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    8.40.05724explicit E-S complexSubstrate
    IP5(13456)

    Product
    PP-IP4
        from Saiardi et al, JBC 275(32); 2000: 24686-92
    2IP6-K  /
    ip5_k1
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    6.699990.2344explicit E-S complexSubstrate
    IP5(13456)

    Product
    PP-IP4
        from Saiardi et al, JBC 275(32); 2000: 24686-92

    IP5(13456) acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1IP5-inhib-5pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 145_dephos
    Pathway No. : 153
    1
    (uM^-1 s^-1)
    45
    (s^-1)
    Kd(bf) = 44.9991(uM)-Substrate
    IP5(13456)
    IP_5pase1

    Product
    IP5-5pase-cmplx
      from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
    2ip5_3pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    0.0003
    (s^-1)
    0
    (s^-1)
    --Substrate
    IP5(13456)

    Product
    IP4(1456)
      Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991 Backflux from the reversible InsP4 3-kinase is not sufficient to maintain Ins(1456)P4 levels. Hence this reaction is necessary. This reaction also maintains the flux in the network.
    3ip5_1pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    0.0136
    (s^-1)
    0
    (s^-1)
    --Substrate
    IP5(13456)

    Product
    IP4(3456)
      InsP5 1-phosphatase Reaction is necessary to generate the flux of Ins(3456)P4 seen physiologically (Ho et al Curr Biol 2002, 12:1-20), although the IP4-1K/pase can maintain basal levels of this InsP4.
    4ip5-kinase-pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    1
    (s^-1)
    1.92
    (s^-1)
    Keq = 1.92(uM)0.342secSubstrate
    IP5(13456)

    Product
    IP6
      Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels
    5IP5-dipp-inhib
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    1
    (uM^-1 s^-1)
    1.6
    (s^-1)
    Kd(bf) = 1.6(uM)-Substrate
    DIPP1
    IP5(13456)

    Product
    IP5-DIPPcmplx
      IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998
    6IP5-inhib-3pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 1345_dephos
    Pathway No. : 156
    1
    (uM^-1 s^-1)
    0.06
    (s^-1)
    Kd(bf) = 0.06(uM)-Substrate
    1345_3pase
    IP5(13456)

    Product
    IP5-3pase-cmplx
      from Hoer and Oberdisse, Biochem J 278; 1991: 219-224

    IP5(13456) acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1ip5(13456)_trp
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    1
    (s^-1)
    0.001
    (s^-1)
    Not applicable**-Substrate
    IP5(13456)_ER

    Product
    IP5(13456)
      Ins(13456)P5 ER-cytosol transport
    2ip4-5K
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    0.15
    (s^-1)
    0.003
    (s^-1)
    Keq = 0.02(uM)6.536secSubstrate
    IP4(1346)

    Product
    IP5(13456)
      Kf based on basal levels of Ins(1346)P4 Kb obtained from dG calculations for equilibrium product substrate conditions.
    3ip4-3k-off
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    4.3
    (s^-1)
    0.2687
    (uM^-1 s^-1)
    Kd(cb) = 0.0625(uM)-Substrate
    ip4_3k_cmplx

    Product
    IP4-3K
    IP5(13456)
      Kf = Vmax for enzyme: Stephens et al, Biochem J 249; 1988. Kb ascertained from dG calculations for equilibrium conditions.
    4ip4-1k-off
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    0.624
    (s^-1)
    0.056
    (uM^-1 s^-1)
    Kd(cb) = 0.0897(uM)-Substrate
    ip4_1k_cmplx

    Product
    IP3-56K_IP4-1K
    IP5(13456)
      Kf = enzyme Vmax : Yang and Shears, Biochem J 2000, 351, 551-5. Kb ascertained from dG calculations for equilibrium product substrate conditions. Ho et al, Curr Biol 2002, 12: 1-20 report a Vmax for reverse reaction of 0.0656 /sec. But this cannot be exactly incorporated unless Km for InsP5 is also known. Simulations show that incorporation of this reverse reaction can maintain basal InsP4 levels but cannot achieve the stimulated InsP4 levels shown in Ho et al. Hence the separate InsP5 1pase is retained.
    5dipp_ip6
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    0
    (s^-1)
    0
    (s^-1)
    --Substrate
    PP-IP4

    Product
    IP5(13456)
      rate based on basal levels of PP-InsP4



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.