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Molecule Parameter List for DIPP1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
DIPP1 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    DIPP1 acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    DIPP1
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    0.12671000No
    Diphosphoinositol-Polyphosphate Phosphohydrolase from Safrany et al, EMBO J 17(22); 1998: 6599-607

    DIPP1 acting as an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1DIPP1 /
    dipp_ip8
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    0.03400350.61654explicit E-S complexSubstrate
    bisPP-IP4

    Product
    PP-IP5
        from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of human recombinant protein, which is 20-50 fold greater than activity of the purified rat enzyme
    2DIPP1 /
    dipp_ip7
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    0.3400065.14explicit E-S complexSubstrate
    PP-IP5

    Product
    IP6
        from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of recombinant human protein which is 20-50 fold greater than activity of the purified rat enzyme

    DIPP1 acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1IP5-dipp-inhib
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    1
    (uM^-1 s^-1)
    1.6
    (s^-1)
    Kd(bf) = 1.6(uM)-Substrate
    DIPP1
    IP5(13456)

    Product
    IP5-DIPPcmplx
      IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998
    2IP6-dipp-inhib
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    1
    (uM^-1 s^-1)
    0.2
    (s^-1)
    Kd(bf) = 0.2(uM)-Substrate
    DIPP1
    IP6

    Product
    IP6-DIPPcmplx
      IC50=0.2uM from Safrany et al, EMBO J 17(22); 1998



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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