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Molecule Parameter List for IP6

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP6 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001161

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP6 acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP6
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    30.00051000No
    Inositol hexakisphosphate Conc from Voglmaier et al, PNAS 93; 1996

    IP6 acting as a Substrate for an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP6_K2  /
    ip6_k2
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    2.999991.6334explicit E-S complexSubstrate
    IP6

    Product
    PP-IP5
    from Saiardi et al, Curr Biol 9; 1999

    IP6 acting as a Product of an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    DIPP1  /
    dipp_ip7
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    0.3400065.14explicit E-S complexSubstrate
    PP-IP5

    Product
    IP6
    from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of recombinant human protein which is 20-50 fold greater than activity of the purified rat enzyme

    IP6 acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1ip6_trp
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    0.001
    (s^-1)
    1
    (s^-1)
    Not applicable**-Substrate
    IP6

    Product
    IP6_ER
      InsP6 ER-cytosol transport. Rate based on cytosolic levels of InsP6. ER-cytosol transport for other inositol phosphates are assigned the same rate as of now, as exact transport rates are not known.
    2IP_4pase-inact
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    1
    (uM^-1 s^-1)
    19
    (s^-1)
    Kd(bf) = 19(uM)-Substrate
    IP6
    IP_4pase

    Product
    IP_4pase_inact
      from Norris et al, JBC 269; 1994
    3IP6-inhib-5pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 145_dephos
    Pathway No. : 153
    1
    (uM^-1 s^-1)
    16
    (s^-1)
    Kd(bf) = 15.9997(uM)-Substrate
    IP6
    IP_5pase1

    Product
    IP6-5pase-inhib
      from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
    4IP6-dipp-inhib
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    1
    (uM^-1 s^-1)
    0.2
    (s^-1)
    Kd(bf) = 0.2(uM)-Substrate
    DIPP1
    IP6

    Product
    IP6-DIPPcmplx
      IC50=0.2uM from Safrany et al, EMBO J 17(22); 1998
    5IP6cmplx-on
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    0.0038
    (uM^-2 s^-1)
    2.376
    (s^-1)
    --Substrate
    ATP
    IP6
    IP6-K

    Product
    IP6-K-complex
      from Voglmaier et al, PNAS 93; 1996 Kf calculated from Km for InsP6 and ATP, and Vmax for forward and backward reactions Kb = Vmax of backward reaction
    6IP6-inhib-3pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 1345_dephos
    Pathway No. : 156
    1
    (uM^-1 s^-1)
    0.003
    (s^-1)
    Kd(bf) = 0.003(uM)-Substrate
    1345_3pase
    IP6

    Product
  • IP6-inhib-3pase-
    cmplx

  •   from Hoer and Oberdisse, Biochem J 278; 1991: 219-224

    IP6 acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip5-kinase-pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IHP-system
    Pathway No. : 155
    1
    (s^-1)
    1.92
    (s^-1)
    Keq = 1.92(uM)0.342secSubstrate
    IP5(13456)

    Product
    IP6
    Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels



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