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Molecule Parameter List for IP6_ER

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP6_ER participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP6_ER acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP6_ER
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    0160No

    IP6_ER acting as a Substrate for an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    MIPP  /
    ip6_pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    0.0002999960.01324explicit E-S complexSubstrate
    IP6_ER

    Product
    IP5(12456)_ER
    IP5(13456)_ER
    InsP6 2/3-phosphatase from Nogimori et al, JBC 266; 1991

    IP6_ER acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip6_trp
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    0.001
    (s^-1)
    1
    (s^-1)
    Not applicable**-Substrate
    IP6

    Product
    IP6_ER
    InsP6 ER-cytosol transport. Rate based on cytosolic levels of InsP6. ER-cytosol transport for other inositol phosphates are assigned the same rate as of now, as exact transport rates are not known.
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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