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Molecule Parameter List for IP4(3456)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP4(3456) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000021

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
    		• 31Network
    MIPP,  CaMKII,  CaM,  
    PKC,  IP3-3K,  CaRegulation,  
    Gq,  PLCbeta,  134_dephos,  
    145_dephos,  IP4-system,  IHP-system,  
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP4(3456) acting as a Molecule in      NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    IP4(3456)
  • NonOsc_Ca_
    IP3metabolism
    Accession No. : 31
    		• IP4-system
    Pathway No. : 154    		1.41000No
    Inositol (3456)tetrakisphosphate basal levels ~ 1.4uM

    IP4(3456) acting as a Substrate in a reaction in      NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1ip4-1k-on
  • NonOsc_Ca_
    IP3metabolism
    Accession No. : 31
    		• IP4-system
    Pathway No. : 154    		31.2001
    (uM^-1 s^-1)    		2.496
    (s^-1)    		Kd(bf) = 0.08(uM)-Substrate
    IP3-56K_IP4-1K
    IP4(3456)

    Product
    ip4_1k_cmplx
      Rates derives from enzyme Km and Vmax values: Yang and Shears, Biochem J 2000, 351: 551-555.
    2IP4-inhib-3pase
  • NonOsc_Ca_
    IP3metabolism
    Accession No. : 31
    		• 1345_dephos
    Pathway No. : 156    		1
    (uM^-1 s^-1)    		0.5
    (s^-1)    		Kd(bf) = 0.5(uM)-Substrate
    1345_3pase
    IP4(3456)

    Product
    IP4-3pase-cmplx
      from Hoer et al, Biochem J 270; 1990

    IP4(3456) acting as a Product in a reaction in      NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip5_1pase
  • NonOsc_Ca_
    IP3metabolism
    Accession No. : 31
    		• IP4-system
    Pathway No. : 154    		0.0136
    (s^-1)    		0
    (s^-1)    		--Substrate
    IP5(13456)

    Product
    IP4(3456)
    InsP5 1-phosphatase Reaction is necessary to generate the flux of Ins(3456)P4 seen physiologically (Ho et al Curr Biol 2002, 12:1-20), although the IP4-1K/pase can maintain basal levels of this InsP4.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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