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Molecule Parameter List for IP1(4)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP1(4) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	1	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	32	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP1(4) acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP1(4)	Osc_Ca_ IP3metabolism Accession No. : 32	145_dephos Pathway No. : 166	0	1000	No
Inositol 4-monophosphate Basal levels = 10% of Ins(1)P1 ~ 4uM Ackermann et al, BiochemJ 242, 1987(2): 517

IP1(4) acting as a Product of an Enzyme in  Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP_1pase  / ip2_1pase	Osc_Ca_ IP3metabolism Accession No. : 32	145_dephos Pathway No. : 166	5.00005	2	4	explicit E-S complex	Substrate IP2(14) Product IP1(4)
from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)

IP1(4) acting as a Substrate in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
4pase-on	Osc_Ca_ IP3metabolism Accession No. : 32	145_dephos Pathway No. : 166	1.035 (uM^-1 s^-1)	157.32 (s^-1)	Kd(bf) = 152(uM)	-	Substrate IP1(4) IP1_pase Product ip1_4pase_cmplx
Rates derived from Ins(4)P1 4-phosphatase Km: Gee et al, Biochem J 249; 1988