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Parameters for CaMKII (Pathway Number 159)
Pathway Basic Parameters
| Pathway Name||CaMKII|
| Pathway Entry Number || 159|
| Accession Number ||32|
| Accession Name ||Osc_Ca_IP3metabolism|
| Species ||Generic mammalian|
| Tissue ||Brain - Neuronal|
| Related Pathways ||13,
| Notes|| Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzymes look a bit complicated. Actually it is just 3 reactions for different sites, by 4 states of CaMKII, defined by the phosphorylation state. This model approximates the fact that the enzyme is actually present as a decamer/dodecamer. It does so by treating the autophosphorylation reactions as being independent of the concentration of CaMKII. Also the rates for the autophosphorylation steps have been scaled to fit this approximation.
|This pathway is part of accession 32 and is completely specified in the file acc32.g.|
There is no separate files for just this pathway.
|Native Format (GENESIS format)|| acc32.g |
|GENESIS Format (Annotated version)|| Anno_acc32.g |
Pathway Detail Molecule List Enzyme List Reaction List
|Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR |
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