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Molecule Parameter List for inact_cap_entry

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

inact_cap_entry participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	32	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

inact_cap_entry acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
inact_cap_entry	Osc_Ca_ IP3metabolism Accession No. : 32	CaRegulation Pathway No. : 170	0	1000	No
represents the portion of the capacitative-Ca entry channel which is blocked when there is lots of Ca sequestered in the stores

inact_cap_entry acting as a Product in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
inactivate_cap_ Ca	Osc_Ca_ IP3metabolism Accession No. : 32	CaRegulation Pathway No. : 170	0 (#^-2 s^-1)	10 (s^-1)	Not applicable**	-	Substrate Ca-sequester Ca-sequester capacitive_Ca_ entry* Product inact_cap_entry
For non-oscillatory Ca dynamics Kd was set at 3 uM. This did not allow for Ca oscillations characteristic of the Othmer-Tang model. The rates here are constrained solely by the need to generate Othmer-Tang type Ca oscillations.

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration