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Molecule Parameter List for ER_pump | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| ER_pump participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
ER_pump acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | ER_pump | Osc_Ca_
IP3metabolism
Accession No. : 32 | Othmer-Tang-mode
l
Pathway No. : 171 | 2 | 1000 | No | | This pump represents the ATP-dependent pump that moves cytosolic Ca into the ER in the Othmer-Tang model. |
ER_pump acting as an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | ER_pump /
ER_pump
| Osc_Ca_
IP3metabolism
Accession No. : 32 | Othmer-Tang-mode
l
Pathway No. : 171 | 0.150007 | 10 | 4 | explicit E-S complex | Substrate
Ca
Product
Ca-sequester
| | Othmer and Tang use a Km of 0.5 uM, but this does not generate proper Ca oscillations in our model. So we have decreased Km to 0.15 uM. This is closer to the 0.1 uM value used by Keizer and De Young in Tang et al, Biophys J 70, 1996 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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