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Molecule Parameter List for mirror_Ca.IP3.IP3R

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
mirror_Ca.IP3.IP3R participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
    		• 32Network
    MIPP,  CaMKII,  CaM,  
    PKC,  IP3-3K,  Gq,  
    PLCbeta,  134_dephos,  145_dephos,  
    IP4-system,  IHP-system,  1345_dephos,  
    CaRegulation,  Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    mirror_Ca.IP3.IP3R acting as a Molecule in      Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    mirror_Ca.IP3.IP3R
  • Osc_Ca_
    IP3metabolism
    Accession No. : 32
  • Othmer-Tang-mode
    l
    Pathway No. : 171
    		• 01000No

    mirror_Ca.IP3.IP3R acting as a Summed Molecule in      Osc_Ca_IP3metabolism Network
    Accession NamePathway NameTargetInput
  • Osc_Ca_
    IP3metabolism
    Accession No. : 32
  • Othmer-Tang-mode
    l
    Pathway No. : 171
    		• mirror_Ca.IP3.IP3RCa.IP3.IP3R

    mirror_Ca.IP3.IP3R acting as a Substrate in a reaction in      Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    actIP3R
  • Osc_Ca_
    IP3metabolism
    Accession No. : 32
  • Othmer-Tang-mode
    l
    Pathway No. : 171
    		• 1000.01
    (uM^-2 s^-1)    		5
    (s^-1)    		Keq = 0.005(uM)-Substrate
  • mirror_
    Ca.IP3.IP3R
  • mirror_
    Ca.IP3.IP3R
  • mirror_
    Ca.IP3.IP3R

    Product
    activeIP3R
    • Rate set so that almost all Ca.IP3.IP3R complex (formed by Ca and IP3 binding to the IP3R) becomes the active Ca conducting channel


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.