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Molecule Parameter List for mirror_Ca.IP3.IP3R

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

mirror_Ca.IP3.IP3R participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	0	0	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	32	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

mirror_Ca.IP3.IP3R acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
mirror_Ca.IP3.IP3R	Osc_Ca_ IP3metabolism Accession No. : 32	Othmer-Tang-mode l Pathway No. : 171	0	1000	No

mirror_Ca.IP3.IP3R acting as a Summed Molecule in  Osc_Ca_IP3metabolism Network

Accession Name	Pathway Name	Target	Input
Osc_Ca_ IP3metabolism Accession No. : 32	Othmer-Tang-mode l Pathway No. : 171	mirror_Ca.IP3.IP3R	Ca.IP3.IP3R

mirror_Ca.IP3.IP3R acting as a Substrate in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
actIP3R	Osc_Ca_ IP3metabolism Accession No. : 32	Othmer-Tang-mode l Pathway No. : 171	1000.01 (uM^-2 s^-1)	5 (s^-1)	Keq = 0.005(uM)	-	Substrate mirror_ Ca.IP3.IP3R mirror_ Ca.IP3.IP3R mirror_ Ca.IP3.IP3R Product activeIP3R
Rate set so that almost all Ca.IP3.IP3R complex (formed by Ca and IP3 binding to the IP3R) becomes the active Ca conducting channel