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Molecule Parameter List for Tot-active-CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*Tot-active-CaMKII* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	2	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII	33	Network	Shared_Object_CaMKII, CaM, CaMKII, CaN
This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original.

Tot-active-CaMKII acting as a Molecule in CaMKII Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Tot-active-CaMKII	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	0	0.1309	No

Tot-active-CaMKII acting as a Summed Molecule in CaMKII Network

Accession Name	Pathway Name	Target	Input
CaMKII Accession No. : 33	CaMKII Pathway No. : 174	Tot-active-CaMKII	CaMKII-CaMCa4 Trapped-T286 Capped Autonomous

Tot-active-CaMKII acting as an Enzyme in CaMKII Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	Tot-active-CaMKI I / phosph_T286	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	0.254651	10	0	explicit E-S complex	Substrate CaMKII-CaMCa4 Product Trapped-T286
	This enzyme represents an intra-holoenzyme reaction from one active subunit to its neighbor. k1 is now in units of 1/sec. The Km, Ratio and Vmax terms are pretty meaningless. The enzyme really is there just to represent the forward rate of 0.5 from CaMKII-CaMCa4 to Trapped-T285. We have a high k3 so that the reac is limited only by k1. The enzyme itself does not have much purpose other than to allow scaling of the overall rate by the proportion of adjacent molecules in the appropriate state.
2	Tot-active-CaMKI I / phosph_T305	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	1.27325	10	0	explicit E-S complex	Substrate Autonomous Product Capped
	This enzyme also represents an intra-holoenzyme reaction. So it is not really treated as an enzyme in Holme's model, more like a probability of reaction that scales according to the number of active CaMKII neighboring subunits. Here we approximate it as an enzyme rate limited by the k1=0.1 step, no back reaction, and with a scaling from Total_CaMKII such that the effective forward rate will simply be the fraction of CaMKII that are active, times 1/10 for nearest neigbors, times k1.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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