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Molecule Parameter List for Sos*.Grb2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sos*.Grb2 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
-fig1c | 35 | Network | Shared_Object_MAPK-bistability-fig1c, Sos, PKC, MAPK, PLA2, Ras, PDGFR |
| Model for figure 1c in Bhalla US et al. Science (2002) 297(5583):1018-23. The demo for this figure is available here. This synaptic signaling model is without the MKP-1 feedback, so it is bistable and remains so over long periods. | |||
Sos*.Grb2 acting as a Molecule in MAPK-bistability-fig1c Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| Sos*.Grb2 | -fig1c Accession No. : 35 | Sos Pathway No. : 180 | 0 | 1000 | No | |
| Inactive complex of Sos* with Grb2 due to phosphorylation of the Sos. See Porfiri and McCormick 1996 JBC 271(10):5871. | ||||||
Sos*.Grb2 acting as a Product in a reaction in MAPK-bistability-fig1c Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| Grb2_bind_Sos* | -fig1c Accession No. : 35 | Sos Pathway No. : 180 | 0.025 (uM^-1 s^-1) | 0.0168 (s^-1) | Kd(bf) = 0.672(uM) | - | Substrate Grb2 Sos* Product Sos*.Grb2 |
| Same rates as Grb2_bind_Sos: Porfiri and McCormick JBC 271:10 pp 5871 1996 show that the binding is not affected by the phosphorylation. | |||||||