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Molecule Parameter List for R | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| R participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
adapt_fb | 45 | Pathway | MAPK |
| This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. | |||
R acting as a Molecule in MAPK_Asthagiri_adapt_fb Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| R | adapt_fb Accession No. : 45 | MAPK Pathway No. : 193 | 0.4274 | 390 | No | |
| R nInit = 10^5 no./cell from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39 | ||||||
R acting as a Substrate in a reaction in MAPK_Asthagiri_adapt_fb Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| L-bind-R | adapt_fb Accession No. : 45 | MAPK Pathway No. : 193 | 0.1666 (uM^-1 s^-1) | 0.005 (s^-1) | Kd(bf) = 0.03(uM) | - | Substrate L R Product C |
| Kf = 10^7/M-1 min-1 and Kr is 0.3 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39 | |||||||