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Accession information for MAPK_Asthagiri_adapt_fb (Accession Number 45)

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Accession Basic Parameters

Name MAPK_Asthagiri_adapt_fb
Accession Type Pathway
Transcriber Pradeep Kumar S, NCBS
Developer Anand R. Asthagiri and Douglas A. Lauffenburger
Entry Date (YYYY-MM-DD) 2003-02-22 00:00:00
Species Chinese hamster (Cricetulus griseus); mammalian
Tissue Ovary - CHO cell line
Cell Compartment Surface, cytosol
Source Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ).
Methodology Quantitative match to experiments, Qualitative
Model Implementation Mathematically equivalent
Model Validation Replicates orginal data, Approximates original data
Notes This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

Conversion formats

Native Format (GENESIS format)    acc45.g   
GENESIS Format (Annotated version)    Anno_acc45.g   
MATLAB format    acc45.m   
SBML format    acc45.xml   

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