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Molecule Parameter List for C

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
C participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_Asthagiri_
    adapt_fb
    		• 45Pathway
    MAPK 
    This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

    C acting as a Molecule in      MAPK_Asthagiri_adapt_fb Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    C
  • MAPK_Asthagiri_
    adapt_fb
    Accession No. : 45
    		• MAPK
    Pathway No. : 193    		0390No
    Ligand bound receptor from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    C acting as a Substrate in a reaction in      MAPK_Asthagiri_adapt_fb Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    C-dimer
  • MAPK_Asthagiri_
    adapt_fb
    Accession No. : 45
    		• MAPK
    Pathway No. : 193    		1
    (uM^-1 s^-1)    		1
    (s^-1)    		Keq = 1(uM)-Substrate
    C
    C

    Product
    C2
    Kc is 6*10^7 M-1 min-1 and Ku is 60 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    C acting as a Product in a reaction in      MAPK_Asthagiri_adapt_fb Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    L-bind-R
  • MAPK_Asthagiri_
    adapt_fb
    Accession No. : 45
    		• MAPK
    Pathway No. : 193    		0.1666
    (uM^-1 s^-1)    		0.005
    (s^-1)    		Kd(bf) = 0.03(uM)-Substrate
    L
    R

    Product
    C
    Kf = 10^7/M-1 min-1 and Kr is 0.3 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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