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Molecule Parameter List for R.GDP.Gabc | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| R.GDP.Gabc participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| PKA_2003 | 47 | Network | Shared_Object_PKA_2003, PKA, AC, Gs |
| This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here. | |||
R.GDP.Gabc acting as a Molecule in PKA_2003 Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| R.GDP.Gabc | PKA_2003 Accession No. : 47 | Gs Pathway No. : 198 | 0 | 1000 | No | |
| Fraction of R.GDP.Gabc is about 50% of total R, from Fay et al. Biochemistry 30:5066-5075(1991) Since this is not the same receptor, this value is a bit uncertain. | ||||||
R.GDP.Gabc acting as a Substrate in a reaction in PKA_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| L-bind-R.Gabc | PKA_2003 Accession No. : 47 | Gs Pathway No. : 198 | 5 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.02(uM) | - | Substrate L R.GDP.Gabc Product L.R.GDP.Gabc |
| From Seifert et al Mol. Pharmacol 56:348-358 (1999) The EC50 for ISO is about 20 nM. | |||||||
R.GDP.Gabc acting as a Product in a reaction in PKA_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| R-bind-Gabc | PKA_2003 Accession No. : 47 | Gs Pathway No. : 198 | 0.2 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.5(uM) | - | Substrate GDP.Gabc R Product R.GDP.Gabc |
| Receptor binding to Gs. Scale it to the same slow rates described by Fay et al for L.R to L.R.G. From detailed balance, Kd is 50. | |||||||