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Molecule Parameter List for PKC-basal* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PKC-basal* participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| PKC_2003 | 48 | Pathway | PKC_2003, PKC |
| This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here. | |||
PKC-basal* acting as a Molecule in PKC_2003 Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| PKC-basal* | PKC_2003 Accession No. : 48 | PKC Pathway No. : 200 | 0.02 | 1000 | No | |
PKC-basal* acting as a Summed Molecule in PKC_2003 Network
| Accession Name | Pathway Name | Target | Input |
| PKC_2003 Accession No. : 48 | PKC_2003 Pathway No. : 199 | PKC-active | PKC-DAG-AA* PKC-Ca-memb* PKC-Ca-AA* PKC-DAG-memb* PKC-basal* PKC-AA* |
| Conc of PKC in brain is about 1 uM (?) | |||
PKC-basal* acting as a Product in a reaction in PKC_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| PKC-basal-act | PKC_2003 Accession No. : 48 | PKC Pathway No. : 200 | 1 (s^-1) | 50 (s^-1) | Keq = 50(uM) | 0.02sec | Substrate PKC-cytosolic Product PKC-basal* |
| Initial basal levels were set by kf = 1, kb = 20. In model, though, the basal levels of PKC activity are higher. | |||||||