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Molecule Parameter List for PKC-AA*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-AA* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
PKC_200348Pathway
PKC_2003 PKC 
This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here.

PKC-AA* acting as a Molecule in  
PKC_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PKC-AA*PKC_2003
Accession No. : 48
PKC
Pathway No. : 200
01000No

PKC-AA* acting as a Summed Molecule in  
PKC_2003 Network
Accession NamePathway NameTargetInput
PKC_2003
Accession No. : 48
PKC_2003
Pathway No. : 199
PKC-activePKC-DAG-AA*
PKC-Ca-memb*
PKC-Ca-AA*
PKC-DAG-memb*
PKC-basal*
PKC-AA*
Conc of PKC in brain is about 1 uM (?)

PKC-AA* acting as a Product in a reaction in  
PKC_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
PKC-act-by-AAPKC_2003
Accession No. : 48
PKC
Pathway No. : 200
0.0001
(uM^-1 s^-1)
0.1
(s^-1)
Kd(bf) = 833.3333(uM)-Substrate
AA
PKC-cytosolic

Product
PKC-AA*
Raise kf from 1.667e-10 to 2e-10 to get better match to data.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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