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Molecule Parameter List for AA | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| AA participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 3 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | PKC_2003 | 48 | Pathway |
PKC_2003, PKC | | This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here. |
AA acting as a Molecule in PKC_2003 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | AA | PKC_2003
Accession No. : 48 | PKC_2003
Pathway No. : 199 | 5 | 1000 | Yes | | |
AA acting as a Substrate in a reaction in PKC_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | PKC-act-by-Ca-AA | PKC_2003
Accession No. : 48 | PKC
Pathway No. : 200 | 0.0012
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 83.3333(uM) | - | Substrate
AA
PKC-Ca
Product
PKC-Ca-AA*
| | | Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match. | | 2 | PKC-act-by-AA | PKC_2003
Accession No. : 48 | PKC
Pathway No. : 200 | 0.0001
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 833.3333(uM) | - | Substrate
AA
PKC-cytosolic
Product
PKC-AA*
| | | Raise kf from 1.667e-10 to 2e-10 to get better match to data. | | 3 | PKC-n-DAG-AA | PKC_2003
Accession No. : 48 | PKC
Pathway No. : 200 | 0.018
(uM^-1 s^-1) | 2
(s^-1) | Kd(bf) = 111.1111(uM) | - | Substrate
AA
PKC-DAG
Product
PKC-DAG-AA
| | | Reduced kf to 0.66X to match Shinomura et al data. Initial: kf = 3.3333e-9 New: 2e-9 Newer: 2e-8 kb was 0.2 now 2. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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