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Molecule Parameter List for PLCr-I | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PLCr-I participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
pathway | 52 | Pathway | EGFR |
| This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421. | |||
PLCr-I acting as a Molecule in EGFR_Signaling_pathway Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| PLCr-I | pathway Accession No. : 52 | EGFR Pathway No. : 223 | 0 | 1.6667E-6 | No | |
| Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. | ||||||
PLCr-I acting as a Product in a reaction in EGFR_Signaling_pathway Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| r25 | pathway Accession No. : 52 | EGFR Pathway No. : 223 | 1 (s^-1) | 0.03 (s^-1) | Keq = 0.03(uM) | 0.971sec | Substrate PLCrP Product PLCr-I |
| Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. | |||||||