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Molecule Parameter List for R-Sh-G

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

R-Sh-G participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	5	0	0	0	2	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
EGFR_Signaling_ pathway	52	Pathway	EGFR
This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

R-Sh-G acting as a Molecule in  EGFR_Signaling_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
R-Sh-G	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0	1.6667E-6	No
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

R-Sh-G acting as a Summed Molecule in  EGFR_Signaling_pathway Network

	Accession Nane	Pathway Name	Target	Input
1	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	pEGFRtot	RP R-PL R-PLP R-G R-G-S R-Sh R-ShP R-Sh-G R-Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total phosphorylated EGFR = 2.([RP] + [R-PL] + [R-PLP] + [R-G] + [R-G-S] + [R-Sh] + [R-ShP] + [R-Sh-G] + [R-Sh-G-S] )
2	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	pShctot	R-ShP R-Sh-G R-Sh-G-S ShP Sh-G Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total phosphorylated Shc = [ShP] + [Sh-G] + [ Sh-G-S] + [R-ShP] [R-Sh-G] + [R-Sh-G-S]
3	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	Grb2_Shc	R-Sh-G Sh-G R-Sh-G-S Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total concentration of Grb2 bound to Shc isoforms= [Sh-G-S] [R-Sh-G] +[R-Sh-G-S] + [Sh-G]
4	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	Shc_EGFR	R-ShP R-Sh-G R-Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Shc bound to EGFR = [R-ShP] + [ R-Sh-G] + [R-Sh-G-S]
5	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	Grb_EGFR	R-G R-G-S R-Sh-G R-Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total concentration of Grb2 bound to EGFR forms = [R-G] + [R-G-S] + [R-Sh-G] + [R-Sh-G-S]

R-Sh-G acting as a Substrate in a reaction in  EGFR_Signaling_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	r19	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	10 (uM^-1 s^-1)	0.0214 (s^-1)	Kd(bf) = 0.0021(uM)	-	Substrate R-Sh-G SOS Product R-Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
2	r18	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.3 (s^-1)	0.9 (uM^-1 s^-1)	Kd(cb) = 3(uM)	-	Substrate R-Sh-G Product RP Sh-G
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

R-Sh-G acting as a Product in a reaction in  EGFR_Signaling_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
r17	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	3 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0333(uM)	-	Substrate Grb R-ShP Product R-Sh-G
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.