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Molecule Parameter List for SOS

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*SOS* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	3	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
EGFR_Signaling_ pathway	52	Pathway	EGFR
This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

SOS acting as a Molecule in EGFR_Signaling_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
SOS	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.001	1.6667E-6	No
The initial concentration is set to 0.95421nM instead of 37nM which. Thanks to Dr. Boris N. Kholodenko for clarifying the ambiguity and furnishing the initial concentration.

SOS acting as a Substrate in a reaction in EGFR_Signaling_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	r19	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	10 (uM^-1 s^-1)	0.0214 (s^-1)	Kd(bf) = 0.0021(uM)	-	Substrate R-Sh-G SOS Product R-Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
2	r22	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	30 (uM^-1 s^-1)	0.064 (s^-1)	Kd(bf) = 0.0021(uM)	-	Substrate SOS Sh-G Product Sh-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
3	r10	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.01 (uM^-1 s^-1)	0.06 (s^-1)	Kd(bf) = 6(uM)	-	Substrate R-G SOS Product R-G-S
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

SOS acting as a Product in a reaction in EGFR_Signaling_pathway Network

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
r12	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.0015 (s^-1)	0.1 (uM^-1 s^-1)	Kd(cb) = 66.6667(uM)	-	Substrate G-S Product Grb SOS
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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