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Molecule Parameter List for enz8

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

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Statistics

*enz8* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
EGFR_Signaling_ pathway	52	Pathway	EGFR
This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

enz8 acting as a Molecule in EGFR_Signaling_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
enz8	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.001	1.6667E-6	No
The initial concentration was set to 1nM. Citation: Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

enz8 acting as an Enzyme in EGFR_Signaling_pathway Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
enz8 / r8	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.1	1	4	Classical Michaelis-Menten V = Etot.S.Kcat/Km+S	Substrate PLCrP Product PLCr
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

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