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Molecule Parameter List for enz16

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

enz16 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
EGFR_Signaling_ pathway	52	Pathway	EGFR
This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

enz16 acting as a Molecule in  EGFR_Signaling_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
enz16	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.001	1.6667E-6	No
Taken from Kholodenko et al 1999.

enz16 acting as an Enzyme in  EGFR_Signaling_pathway Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
enz16 / r16	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.34	1.7	4	Classical Michaelis-Menten V = Etot.S.Kcat/Km+S	Substrate ShP Product Shc
Taken from Kholodenko et al 1999.