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Molecule Parameter List for pShctot

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
pShctot participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • EGFR_Signaling_
    pathway
    		• 52Pathway
    EGFR 
    This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999.
    Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

    pShctot acting as a Molecule in      EGFR_Signaling_pathway Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    pShctot
  • EGFR_Signaling_
    pathway
    Accession No. : 52
    		• EGFR
    Pathway No. : 223    		01.6667E-6No
    Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total phosphorylated Shc = [ShP] + [Sh-G] + [ Sh-G-S] + [R-ShP] [R-Sh-G] + [R-Sh-G-S]

    pShctot acting as a Summed Molecule in      EGFR_Signaling_pathway Network
    Accession NamePathway NameTargetInput
  • EGFR_Signaling_
    pathway
    Accession No. : 52
    		• EGFR
    Pathway No. : 223    		pShctotR-ShP
    R-Sh-G
    R-Sh-G-S
    ShP
    Sh-G
    Sh-G-S
    Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total phosphorylated Shc = [ShP] + [Sh-G] + [ Sh-G-S] + [R-ShP] [R-Sh-G] + [R-Sh-G-S]


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.