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Molecule Parameter List for SOS_EGFR

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

SOS_EGFR participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
EGFR_Signaling_ pathway	52	Pathway	EGFR
This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

SOS_EGFR acting as a Molecule in  EGFR_Signaling_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
SOS_EGFR	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0	1.6667E-6	No
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total Sos bound to EGFR = [R-G-S] + [R-Sh-G-S]

SOS_EGFR acting as a Summed Molecule in  EGFR_Signaling_pathway Network

Accession Name	Pathway Name	Target	Input
EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	SOS_EGFR	R-G-S R-Sh-G-S
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total Sos bound to EGFR = [R-G-S] + [R-Sh-G-S]