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Molecule Parameter List for SOS_EGFR

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
SOS_EGFR participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • EGFR_Signaling_
    pathway
    		• 52Pathway
    EGFR 
    This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999.
    Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

    SOS_EGFR acting as a Molecule in      EGFR_Signaling_pathway Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    SOS_EGFR
  • EGFR_Signaling_
    pathway
    Accession No. : 52
    		• EGFR
    Pathway No. : 223    		01.6667E-6No
    Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total Sos bound to EGFR = [R-G-S] + [R-Sh-G-S]

    SOS_EGFR acting as a Summed Molecule in      EGFR_Signaling_pathway Network
    Accession NamePathway NameTargetInput
  • EGFR_Signaling_
    pathway
    Accession No. : 52
    		• EGFR
    Pathway No. : 223    		SOS_EGFRR-G-S
    R-Sh-G-S
    Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total Sos bound to EGFR = [R-G-S] + [R-Sh-G-S]


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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