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Molecule Parameter List for CheYp

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CheYp* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	7	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Chemotaxis	55	Pathway	Chemotaxis
All parameters used are from the .BCT files for BCT1.1 provided by Matthew Levin from the Computational Biology Group in the Department of Zoology at the University of Cambridge.Bias does not reach 0.7, there is a lag in the response of bias to the 5 sec 1 uM Aspartate pulse as shown by Bray et al. Mol.Biol.Cell (1993) 4(5): 469-482. The June 2003 version of the BCT program is BCT4.3 and is available at the computational biology site of the Zoology department at Cambridge University.

CheYp acting as a Molecule in Chemotaxis Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CheYp	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	0.01	1.41	No
CheYp = 1.24e-07 M = 1.24e-01 uM As per Signal 22 in 1SIG_B.BCT provided by Matthew Levin CheYp = 1e-08 M = 1e-2 uM As per Set_Yp configuration in 1CONFIG.BCT provided by Matthew Levin Cell volume = 1.41e-15 L Table 1 pp.474 Bray et al 1993, Mol.Biol.Cell 4: 469-482

CheYp acting as a Substrate in a reaction in Chemotaxis Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Autodephosphoryl ation[1]	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	0.037 (s^-1)	0 (s^-1)	-	-	Substrate CheYp Product CheY
	Tar-CheW complex TW = 1.88e-06 M = 1.88 uM As per Signal entry 3 in 1SIG_B.BCT provided by Matthew Levin Cell volume = 1.41e-15 L Table 1 pp.474 Bray et al 1993, Mol.Biol.Cell 4: 469-482
2	Dephosphorylatio n	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	0.5 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate CheYp CheZ Product CheY
	Ni bound Tar Ni-Tar = 0 M As per Signal 4 in 1SIG_B.BCT provided by Matthew Levin Cell volume = 1.41e-15 L Table 1 pp.474 Bray et al 1993, Mol.Biol.Cell 4: 469-482
3	Dephosphorylatio n[1]	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	99.9972 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate CheYp TaWA Product CheY
	MYpYpYp = 4.47e-10 M = 4.47e-4 uM As per Signal 26 in 1SIG_B.BCT provided by Matthew Levin Cell volume = 1.41e-15 L Table 1 pp.474 Bray et al 1993, Mol.Biol.Cell 4: 469-482
4	Complexing[3]	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	88.0009 (uM^-1 s^-1)	5.5 (s^-1)	Kd(bf) = 0.0625(uM)	-	Substrate CheYp Motor Product MYp
	CheYp complexes with Flagellar Motor (M) Kf = 0.88/Set_Yp = 0.88/1e-08 /sec/M = 0.88e+2/sec/uM Kb = 5.5 /sec As per EXEC.C provided by Matthew Levin Bray et al 1993, Mol.Biol.Cell 4: 469-482
5	Complexing[4]	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	285 (uM^-1 s^-1)	6.64 (s^-1)	Kd(bf) = 0.0233(uM)	-	Substrate CheYp MYp Product MYpYp
	CheYp complexes with MYp Kf = 2.85/Set_Yp = 2.85/1e-08 /sec/M = 2.85e+2/sec/uM Kb = 6.64 /sec As per EXEC.C provided by Matthew Levin Bray et al 1993, Mol.Biol.Cell 4: 469-482
6	Complexing[5]	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	693.999 (uM^-1 s^-1)	5.1 (s^-1)	Kd(bf) = 0.0073(uM)	-	Substrate CheYp MYpYp Product MYpYpYp
	Tar-Ni-CheW-CheA complex TnWA = 0 M As per Signal 15 in 1SIG.BCT provided by Matthew Levin Cell volume = 1.41e-15 L Table 1 pp.474 Bray et al 1993, Mol.Biol.Cell 4: 469-482
7	Complexing[6]	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	2006.97 (uM^-1 s^-1)	5.5 (s^-1)	Kd(bf) = 0.0027(uM)	-	Substrate CheYp MYpYpYp Product MYpYpYpYp
	CheYp complexes with MYpYpYp Kf = 20.07/Set_Yp = 20.07/1e-08 /sec/M = 20.07e+2 /sec/uM Kb = 5.5 /sec As per EXEC.C provided by Matthew Levin Bray et al 1993, Mol.Biol.Cell 4: 469-482

CheYp acting as a Product in a reaction in Chemotaxis Network

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Phosphotransfer[ 1]	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	0.27 (uM^-1 s^-1)	0 (uM^-1 s^-1)	-	-	Substrate CheAp CheY Product CheA CheYp
	Phosphotransfer from CheAp to CheY Kf = 2 10e+05 /sec/M = 0.2 /sec/uM Kb = 0 /sec/M Bray et al 1993, Mol.Biol.Cell 4: 469-482 Table 2 pp.475 Reaction Scheme 5*
2	Autophosphorylat ion[2]	Chemotaxis Accession No. : 55	Chemotaxis Pathway No. : 226	0 ()	0 (s^-1)	-	-	Substrate - Product CheYp
	Autophosphorylation of CheY, Paper says reaction not applicable Table 2 pp.475 Reaction Scheme 6, kf = 0/sec kb = 0/sec As per Reaction 14 in 1REACT.BCT provided by Matthew Levin Bray et al 1993, Mol.Biol.Cell 4: 469-482

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