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Molecule Parameter List for TWA | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | Chemotaxis | 55 | Pathway | Chemotaxis | All parameters used are from the .BCT files for BCT1.1 provided by Matthew Levin from the Computational Biology Group in the Department of Zoology at the University of Cambridge.Bias does not reach 0.7, there is a lag in the response of bias to the 5 sec 1 uM Aspartate pulse as shown by Bray et al. Mol.Biol.Cell (1993) 4(5): 469-482. The June 2003 version of the BCT program is BCT4.3 and is available at the computational biology site of the Zoology department at Cambridge University. |
TWA acting as a Molecule in Chemotaxis Network
Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | TWA | Chemotaxis Accession No. : 55 | Chemotaxis Pathway No. : 226 | 0.212 | 1.41 | No | Tar-CheW-CheA complex TWA = 2.12e-07 M = 2.12e-1 uM As per Signal entry 13 in 1SIG_B.BCT provided by Matthew Levin Cell volume = 1.41e-15 L Table 1 pp.474 Bray et al 1993, Mol.Biol.Cell 4: 469-482 |
TWA acting as a Substrate in a reaction in Chemotaxis Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | Autophosphorylat ion[1] | Chemotaxis Accession No. : 55 | Chemotaxis Pathway No. : 226 | 0.0757 (uM^-1 s^-1) | 0 (s^-1) | - | - | Substrate CheA TWA
Product CheAp
| TWA stimulated autophosphorylation of CheA TWA is complex of Tar, CheW and CheA Kf = 7.57*10e+04 /sec/M = 0.0757 /sec/uM As per Reaction 9 in 1REACT.BCT provided by Matthew Levin Kf = 5.9*10e+4 /sec/M = 0.059 /sec/uM Kb = 0 /sec Bray et al 1993, Mol.Biol.Cell 4: 469-482 Table 2 pp.475 Reaction Scheme 2 |
TWA acting as a Product in a reaction in Chemotaxis Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | 1 | Binding[2] | Chemotaxis Accession No. : 55 | Chemotaxis Pathway No. : 226 | 0.4 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 2.5(uM) | - | Substrate CheA TW
Product TWA
| | MYpYpYpYp = 1.51e-09 M = 1.51e-3 uM As per Signal 27 in 1SIG_B.BCT provided by Matthew Levin Cell volume = 1.41e-15 L Table 1 pp.474 Bray et al 1993, Mol.Biol.Cell 4: 469-482 | 2 | Complexing[7] | Chemotaxis Accession No. : 55 | Chemotaxis Pathway No. : 226 | 0.4 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 2.5(uM) | - | Substrate CheW TA
Product TWA
| | Denominator value to calculate bias as stated on pp.471 Bias = [M + MYp] / [M + MYp + MYpYp + MYpYpYp + MYpYpYpYp] Bray et al 1993, Mol.Biol.Cell 4: 469-482 | 3 | Binding[9] | Chemotaxis Accession No. : 55 | Chemotaxis Pathway No. : 226 | 0.4 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 2.5(uM) | - | Substrate Tar WA
Product TWA
| | Binding of Tar and CheW-CheA complex Kd = 2 uM and therefore Kf also suggested as 0.5 /sec/uM Kf = 4e+05 /sec/M = 0.4 /sec/uM Kb = 1 /sec Bray et al 1993, Mol.Biol.Cell 4: 469-482 Table 3 pp.476 Reaction Scheme 8 |
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