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Molecule Parameter List for neurogranin*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

neurogranin* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	2	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model0	59	Network	Shared_Object_AMPAR_traff_model0, CaMKII, CaM, PP1, PP2B, PP1_PSD, PKA, AC, AMPAR, AMPAR_memb
This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

neurogranin* acting as a Molecule in AMPAR_traff_model0 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
neurogranin*	AMPAR_traff_ model0 Accession No. : 59	CaM Pathway No. : 236	0	0.09	No
The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993)

neurogranin* acting as a Substrate for an Enzyme in AMPAR_traff_model0 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
CaM_Ca_n-CaNAB / dephosph_ neurogranin	AMPAR_traff_ model0 Accession No. : 59	PP2B Pathway No. : 238	10.012	0.67	3.98507	explicit E-S complex	Substrate neurogranin* Product neurogranin
From Seki et al ABB 316(2):673-679

neurogranin* acting as a Product of an Enzyme in AMPAR_traff_model0 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PKC-active / PKC-phosph-neuro granin	AMPAR_traff_ model0 Accession No. : 59	Shared_Object_ AMPAR_traff_ model0 Pathway No. : 234	28.6273	0.58	4.03448	explicit E-S complex	Substrate neurogranin Product neurogranin*
	Rates from Huang et al ABB 305:2 570-580 1993
2	PKC-active / PKC-phosph-ng-Ca M	AMPAR_traff_ model0 Accession No. : 59	Shared_Object_ AMPAR_traff_ model0 Pathway No. : 234	28.5956	0.35	4	explicit E-S complex	Substrate neurogranin-CaM Product CaM neurogranin*
	Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993

neurogranin* acting as a Substrate in a reaction in AMPAR_traff_model0 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dephosph-neurogr anin	AMPAR_traff_ model0 Accession No. : 59	CaM Pathway No. : 236	0.005 (s^-1)	0 (s^-1)	-	-	Substrate neurogranin* Product neurogranin
This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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