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Molecule Parameter List for PP2A | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| PP2A participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 4 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_traff_
model0 | 59 | Network |
Shared_Object_AMPAR_traff_model0, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
PKA, AC, AMPAR,
AMPAR_memb | | This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a
non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno
ver reactions for AMPAR. |
PP2A acting as a Molecule in AMPAR_traff_model0 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PP2A | AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 0.1111 | 0.09 | No | | |
PP2A acting as an Enzyme in AMPAR_traff_model0 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PP2A /
PP2A-dephosph-I1
| AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
I1*
Product
I1
| | | PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6 | | 2 | PP2A /
PP2A-dephosph-PP
1-I*
| AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | k1 changed from 3.3e-6 to 6.6e-6 | | 3 | PP2A /
PP2A-dephosph-I1
_
PSD
| AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
I1*
Product
I1
| | | PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6 | | 4 | PP2A /
PP2A-dephosph-PP
1-I*_
PSD
| AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | k1 changed from 3.3e-6 to 6.6e-6 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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