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Molecule Parameter List for CaMKII-thr286-CaM-PSD | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_traff_
model1 | 60 | Network |
Shared_Object_AMPAR_traff_model1, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
PKA, AC, AMPAR,
AMPAR_memb | | This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable. |
CaMKII-thr286-CaM-PSD acting as a Molecule in AMPAR_traff_model1 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | CaMKII-thr286-CaM-PSD | AMPAR_traff_
model1
Accession No. : 60 | CaMKII
Pathway No. : 245 | 0 | 0.01 | No | | |
CaMKII-thr286-CaM-PSD acting as a Summed Molecule in AMPAR_traff_model1 Network
CaMKII-thr286-CaM-PSD acting as a Substrate for an Enzyme in AMPAR_traff_model1 Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PP1-active_PSD /
Deph-thr286 | AMPAR_traff_
model1
Accession No. : 60 | PP1_PSD
Pathway No. : 249 | 1.99994 | 2.5 | 4 | explicit E-S complex | Substrate
CaMKII-thr286-Ca
M-PSD
Product
CaMKII-CaM-PSD
|
CaMKII-thr286-CaM-PSD acting as a Product of an Enzyme in AMPAR_traff_model1 Network
CaMKII-thr286-CaM-PSD acting as a Product in a reaction in AMPAR_traff_model1 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | transloc_2 | AMPAR_traff_
model1
Accession No. : 60 | CaMKII
Pathway No. : 245 | 0
(#^-1 s^-1) | 0
(s^-1) | Not applicable** | - | Substrate
CaMKII-thr286*-C
aM
NMDAR
Product
CaMKII-thr286-Ca
M-PSD
| | | Same as for transloc_1 | | 2 | CaMKII-thr286-bi
nd-CaM-PSD | AMPAR_traff_
model1
Accession No. : 60 | CaMKII
Pathway No. : 245 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate
CaM-Ca4-PSD
CaMKII-thr286-PS
D
Product
CaMKII-thr286-Ca
M-PSD
| | | Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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