| Name | CaMKII_model3 |
| Accession Type | Network |
| Transcriber | Upinder S. Bhalla, NCBS |
| Developer | Arnold Hayer and Upinder S. Bhalla, NCBS |
| Entry Date (YYYY-MM-DD) | 2005-07-19 00:00:00 |
| Species | General Mammalian |
| Tissue | Neuronal |
| Cell Compartment | Synaptic Spine, Postsynaptic Density |
| Source | Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication ) |
| Methodology | Quantitative match to experiments, Qualitative |
| Model Implementation | Exact GENESIS implementation |
| Model Validation | Replicates original data , Approximates original data |
| Notes | This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs. |
